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Histiocytosis Program

The Histiocytosis Program at Children’s Hospital and Vanderbilt University Medical Center offers comprehensive diagnostic, consultative and therapeutic services for children with histiocytic disorders. These disorders can affect any part of the body. They include Langerhans cell histiocytosis (LCH; also known as eosinophilic granuloma or histiocytosis X), hemophagocytic lymphohistiocytosis (HLH), Rosai-Dorfman disease (RDD; also known as sinus histiocytosis with massive lymphadenopathy), juvenile xanthogranuloma (JXG) and other less common histiocytic disorders.

Children's Hospital provides consultations for patients with newly diagnosed or recurrent histiocytosis. We also offer individualized treatment plans for patients with newly diagnosed or recurrent histiocytosis, and we participate in international clinical trials conducted by the Histiocyte Society.

Conditions We Treat

We treat all conditions related to pediatric histiocytosis, including:

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    Hemophagocytic lymphohistiocytosis (HLH)
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    Juvenile xanthogranuloma (JXG)
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    Rosai-Dorfman disease (RDD)

Meet Your Care Team

Debra L. Friedman

Debra L. FriedmanMD, MS

    Division of Pediatric Hematology/Oncology, General Hematology and Oncology, Leukemia and Lymphoma, Pediatric Hematology/Oncology, Solid Organ Malignancies
Sara Zarnegar-Lumley
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Sara Zarnegar-LumleyMD, MS, BA

    General Hematology and Oncology, Leukemia and Lymphoma, Pediatric Hematology/Oncology

Why Choose Care for Histiocytosis At Children's Hospital

  • Collaborative care

    Our physicians collaborate with experts around the nation through the Children’s Oncology Group and the Histiocyte Society to bring the latest treatments and clinical trial options.

  • Personalized care

    We offer a personalized approach to your child’s care through the collaboration of experts from oncology, ophthalmology, orthopedics, radiation oncology, surgery, neurosurgery, nursing, child life, social work, psychology, physical and occupational therapy and nutrition.

  • Recognized care

    U.S. News & World Report has ranked Children's Hospital as one of the best pediatric cancer programs in the nation.

Tests, Treatments and Services

We offer a full range of tests, treatments and services, including:

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    Radiation therapy
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