Aplastic Anemia and Bone Marrow Failure Disorders

Children can develop a condition called aplastic anemia. This happens when their bone marrow does not make enough of all of the types of blood cells. The Aplastic Anemia and Bone Marrow Failure Disorders program at Children's Hospital offers expert care and treatment of these bone marrow disorders.

Different types of blood cells (red blood cells, white blood cells and platelets) are made in the bone marrow. These cells have different jobs in the body: white blood cells help fight infections; red blood cells carry oxygen from the lungs to the body; the platelets help form blood clots.

Aplastic anemia can develop if

  • A child is born with a bone marrow failure disorder 
  • A child’s bone marrow stops working unexpectedly with no known cause 

Because this condition requires comprehensive care and clinical expertise, a correct diagnosis from the beginning is important.

Services we offer

  • Comprehensive, family-centered care
  • Specialized testing for bone marrow failure disorders
  • Education and counseling
  • Advocacy programs with local, regional, and national organizations
  • Participation in clinical trials and research

Conditions We Treat

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    Idiopathic aplastic anemia
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    Diamond-Blackfan anemia (DBA)
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    Fanconi anemia
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    Dyskeratosis congenita (DC)
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    Paroxysmal nocturnal hemoglobinuria (PNH)
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    Shwachman-Diamond syndrome (SDS)
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    Other rare bone marrow failure disorders

Meet Your Care Team

Alexandra J. Borst
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Alexandra J. BorstMD

    Pediatric Hematology/Oncology
James A. Connelly

James A. ConnellyMD, BS

    Pediatric Hematology/Oncology
Heather L. McDaniel
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Heather L. McDanielMD, MSCI

    Pediatric Hematology/Oncology
Jennifer A. Murdock

Jennifer A. MurdockMD

    Blood Banking and Transfusion Medicine
Emmanuel J. Volanakis

Emmanuel J. VolanakisMD

    Pediatric Hematology/Oncology

Why Choose Care at Children’s Hospital for Pediatric Hematology

  • Experienced care

    Our medical professionals and family support team members have experience and special interest in caring for children and young adults with blood disorders. We work closely with your family to determine the best treatment options and approach.

  • Dedicated lab services

    Our clinic offers comprehensive laboratory services to quickly and accurately make the correct diagnosis to bring treatment sooner to your child.

  • Convenient care

    For those who need them, we can provide blood transfusion and intravenous medicine infusions in our clinic. This maximizes convenience and safety.

  • Innovative treatments

    The medical professionals and support staff on our stem cell transplant team evaluate and treat patients diagnosed with aplastic anemia if a transplant is needed.

Tests, Treatments and Services

We offer a full range of tests, treatments, and services including:

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    Blood product transfusions
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    Genetic testing and counseling
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    Medication management


2200 Children's Way, 6th Floor
Nashville, TN 37232
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